Relapsing subacute demyelinating encephalomyelitis in rats during the course of coronavirus JHM infection
Identifieur interne : 000068 ( Istex/Curation ); précédent : 000067; suivant : 000069Relapsing subacute demyelinating encephalomyelitis in rats during the course of coronavirus JHM infection
Auteurs : Helmut Wege [Allemagne] ; Rihito Watanabe [Allemagne] ; Volker Ter Meulen [Allemagne]Source :
- Journal of Neuroimmunology [ 0165-5728 ] ; 1984.
English descriptors
- Teeft :
- Allergic encephalomyelitis, Arrow heads, Autoimmune reaction, Blue staining, Brain tissue, Cell infiltrations, Chronic relapsing, Clinical signs, Clinical symptoms, Coronavirus, Demyelinated plaque, Demyelinating, Demyelination, Density gradient, Electron microscopy, Encephalomyelitis, First attack, Fresh demyelinating lesions, Grey matter, Incubation period, Infection, Infectious virus, Intracerebral inoculation, Lesion, Lewis rats, Mouse hepatitis virus, Multiple sclerosis, Mutant, Myelin, Myelin debris, Neutralizing antibodies, Plaque, Rat, Recurrent demyelination, Relapsing, Relapsing demyelination, Remyelinated area, Remyelinated areas, Routine coronavirus, Same level, Schwann cells, Serum dilution, Several weeks, Severe paralysis, Sodium chloride, Spinal, Spinal cord, Viral antigens, Virus, Virus infection, Visna virus, Wege, White matter, Wild type.
Abstract
Abstract: Temperature-sensitive mutants of the murine coronavirus JHM induced a subacute demyelinating encephalomyelitis (SDE) in young rats. Neurological symptoms were associated with marked lesions of primary demyelination in the white matter of the central nervous system (CNS), and developing after an incubation time of several weeks to months. Many rats survived this infection and recovered completely from this CNS disease. Among 43 survivors of SDE, 9 rats developed a relapse 27–153 days after onset of the first attack. Neuropathological examination of these animals revealed areas of fresh demyelination together with old remyelinated lesions. Viral antigens were detectable in the neighbourhood of fresh lesions and in some cases infectious virus was re-isolated from rats revealing low antibody titers to JHM virus. These results demonstrate that mutants of JHM virus can induce a relapsing demyelinating disease process, associated with a persistent infection, which possesses some similarities to chronic experimental allergic encephalomyelitis.
Url:
DOI: 10.1016/0165-5728(84)90022-5
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Rihito" uniqKey="Watanabe R" first="Rihito" last="Watanabe">Rihito Watanabe</name><affiliation wicri:level="1"><mods:affiliation>Institute of Virology and Immunobiology, University of Würzburg, D-8700 Würzburg, F.R.G.</mods:affiliation><country xml:lang="fr" wicri:curation="lc">Allemagne</country><wicri:regionArea>Institute of Virology and Immunobiology, University of Würzburg, D-8700 Würzburg</wicri:regionArea></affiliation></author><author><name sortKey="Ter Meulen, Volker" sort="Ter Meulen, Volker" uniqKey="Ter Meulen V" first="Volker" last="Ter Meulen">Volker Ter Meulen</name><affiliation wicri:level="1"><mods:affiliation>Institute of Virology and Immunobiology, University of Würzburg, D-8700 Würzburg, F.R.G.</mods:affiliation><country xml:lang="fr" wicri:curation="lc">Allemagne</country><wicri:regionArea>Institute of Virology and Immunobiology, University of Würzburg, D-8700 Würzburg</wicri:regionArea></affiliation></author></analytic><monogr></monogr><series><title level="j">Journal of Neuroimmunology</title><title level="j" type="abbrev">JNI</title><idno type="ISSN">0165-5728</idno><imprint><publisher>ELSEVIER</publisher><date type="published" when="1984">1984</date><biblScope unit="volume">6</biblScope><biblScope unit="issue">5</biblScope><biblScope unit="page" from="325">325</biblScope><biblScope unit="page" to="336">336</biblScope></imprint><idno type="ISSN">0165-5728</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0165-5728</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="Teeft" xml:lang="en"><term>Allergic encephalomyelitis</term><term>Arrow heads</term><term>Autoimmune reaction</term><term>Blue staining</term><term>Brain tissue</term><term>Cell infiltrations</term><term>Chronic relapsing</term><term>Clinical signs</term><term>Clinical symptoms</term><term>Coronavirus</term><term>Demyelinated plaque</term><term>Demyelinating</term><term>Demyelination</term><term>Density gradient</term><term>Electron microscopy</term><term>Encephalomyelitis</term><term>First attack</term><term>Fresh demyelinating lesions</term><term>Grey matter</term><term>Incubation period</term><term>Infection</term><term>Infectious virus</term><term>Intracerebral inoculation</term><term>Lesion</term><term>Lewis rats</term><term>Mouse hepatitis virus</term><term>Multiple sclerosis</term><term>Mutant</term><term>Myelin</term><term>Myelin debris</term><term>Neutralizing antibodies</term><term>Plaque</term><term>Rat</term><term>Recurrent demyelination</term><term>Relapsing</term><term>Relapsing demyelination</term><term>Remyelinated area</term><term>Remyelinated areas</term><term>Routine coronavirus</term><term>Same level</term><term>Schwann cells</term><term>Serum dilution</term><term>Several weeks</term><term>Severe paralysis</term><term>Sodium chloride</term><term>Spinal</term><term>Spinal cord</term><term>Viral antigens</term><term>Virus</term><term>Virus infection</term><term>Visna virus</term><term>Wege</term><term>White matter</term><term>Wild type</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Abstract: Temperature-sensitive mutants of the murine coronavirus JHM induced a subacute demyelinating encephalomyelitis (SDE) in young rats. Neurological symptoms were associated with marked lesions of primary demyelination in the white matter of the central nervous system (CNS), and developing after an incubation time of several weeks to months. Many rats survived this infection and recovered completely from this CNS disease. Among 43 survivors of SDE, 9 rats developed a relapse 27–153 days after onset of the first attack. Neuropathological examination of these animals revealed areas of fresh demyelination together with old remyelinated lesions. Viral antigens were detectable in the neighbourhood of fresh lesions and in some cases infectious virus was re-isolated from rats revealing low antibody titers to JHM virus. These results demonstrate that mutants of JHM virus can induce a relapsing demyelinating disease process, associated with a persistent infection, which possesses some similarities to chronic experimental allergic encephalomyelitis.</div></front></TEI></record>Pour manipuler ce document sous Unix (Dilib)
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